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| 1854 |
| | | US minister to Mexico James Gadsden secures a treaty by which the USA purchases from Mexico much of southern Arizona | |
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| 1854 |
| | | Austrian monk Gregor Mendel begins his study of pea plants in the garden of the Abbey of St Thomas in Brno | |
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| 1854 |
| | | William Baikie, on an expedition up the Niger, protects his men from malaria by administering quinine | |
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| 1854 |
| | | Ferdinand de Lesseps is granted the concession to construct a canal from the Mediterranean to the Red Sea | |
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| 1854 |
| | | Australian gold diggers, angered by the requirement to purchase a licence, make a defiant stand at the Eureka stockade | |
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| 1854 |
| | | English physician John Snow proves that cholera is spread by infected water (from a pump in London's Broad Street) | |
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| 1854 |
| | | Britain and France enter the war between Turkey and Russia, on the Turkish side | |
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| 1854 |
| | | A London editor decides to send a reporter, William Howard Russell ('Russell of The Times'), to the Crimean front | |
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| 1854 |
| | | Thoreau publishes an account of his two years of self-sufficient transcendentalism in his hut at Walden Pond | |
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| 1854 |
| | | British and French troops land at Sebastopol, to besiege the port, and win a limited victory over the Russians at the river Alma | |
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